Python is an Ultimate submachine gun in The First Descendant that can blast enemies. While grinding to get the Python can be a bit of a pain, it's worth it. The weapon is easy to build and is a strong option for normal missions and Void Intercept Battles.

If you've already unlocked Python, this is the best Python build in The First Descendant.

Python is one of the weapons that you can't build Critical Hit on in The First Descendant because its base Firearm Critical Hit Rate is only five percent. Instead, Python has a double Weak Point Damage multiplier and a Unique Ability that requires you to land Weak Point hits.

The Unique Ability applies stacks of Prey to Weak Point hits, reducing the enemy's resistance to Toxic and Non-Attribute damage. Try to put some Toxic ATK on the weapon as well to take advantage of this perk.