The Rune of Ascendance gives the player the chance to roll the dice and turn one of their items into a unique one of the same kind. It can be tricky to judge what the best use case is for the Rune of Ascendance, but I'll tackle and explain everything in this guide.
Final Age – Unique Targets with Rune of Ascendancy
The best use case for the Rune of Ascendance is if you want to get a unique item that is very hard to find in the Monoliths. For example, the Herald of Scurry is a very rare item drop in The Black Sun monolith, but it is the centerpiece of the Beastmaster Squirrel Build. You can use the Rune of Ascendance to potentially transform one of your helmets into a Herald of Scurry!
A major drawback of the Rune of Ascendance is that the chances of crafting a legendary item are very slim. You can use a Runes of Ascendance Calculator to simulate your chances of getting the item you want.
Currently, there is only one item that specifically requires the Rune of Ascendance, the Fractured Crown. The Fractured Crown contains the Spell Critical Strike Chance affix, which is an essential part of increasing your damage output as a mage.