While Angelbreath can be found in various places on the map and while exploring, you can use this resource even more importantly in Diablo 4 if you have Vessel of Hatred. The Seething Opal of Socketables elixir, which gives you more Gem Fragments and Runes, along with Reputation and 15% XP gain for 30 minutes, requires 3 Angelbreath each time.
How to farm Angelbreath fast, 400/500 per hour! | Diablo 4 guides
There’s more! Season 6’s Season Journey has a goal related to this resource, and since the difficulty levels have changed since Season 6, you’ll want to focus on upgrading Health Potions, which is where Angelbreath comes in handy. In the endgame, you’ll need it to reroll stats on Affixes, so players can easily farm it here.
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Your best chance to get Angelbreath in larger quantities is through Helltide events (by opening the chests) and also through Nightmare Dungeons which you can farm. Additionally, the third best option is to find Herb Caches which you can find while exploring or doing side quests.