As a true demigod in Elden Ring's very large, very confusing pantheon, it makes sense that Miquella the Kind would have her own corresponding Great Rune for players to loot. So where is this thing?
ELDEN RING Shadow of the Earth Tree: Use Miquella's Great Rune to dispel his charms
Unlike all other Great Runes, this one cannot be claimed by defeating its holder. As you know, Miquella threw off all his possessions and his entire body, which of course also applies to the Great Rune that was entrusted to him.
You'll have to track down an entirely different boss in one of the furthest reaches of the Land of Shadow, but all this effort could just save your life.
In true Elden Ring style, Miquella’s Great Rune is hidden behind an absolutely crushing boss fight. You’ll find it in Scaduview on the northern edge of the map, guarded by the Scadutree Avatar, who arguably claims the title of the world’s deadliest sunflower. This behemoth of a boss has a whopping three separate health bars, so it’s probably worth collecting a few Scadutree Fragments to help you survive this war of attrition.