Fists of Fate is a unique pair of gloves from Ancestral in Diablo 4 that now grants incredible attack speed, critical chance, increased damage, and a lucky hit chance. The best part is that it is suitable for all classes, but it can be a challenge to obtain.
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There are two ways to obtain Fists of Fate in Diablo 4: As a drop from the Beast in the Ice or by defeating enemies and opening chests in World Tiers Three and Four.
You have a chance to get Fists of Fate in World Tiers Three and Four by opening chests and defeating enemies. Even if you open chests and defeat enemies in these higher tiers, you are not guaranteed to get the Fists. So it is not a reliable way to get these gloves and it is too cumbersome to use as a farming method.
If you're lucky enough to come across these gloves that's great, but if your RNG is as bad as mine then you're not going to get these gloves using this method.