This article explains how to quickly send a message in the Apple Mail app, as well as other keyboard shortcuts. The Instructions article applies to Mail 5 (in Mac OS X Lion) and later.
How to Organize or Hide Thousands of Emails in Mac Mail – in 4 Easy Steps
Press Command+Shift+D and Mail will send your email without you having to select Send Message in the upper-left corner of the window.
Once you start using keyboard shortcuts in Mail, you'll probably want to add a few more handy keystrokes.
Try out more Mail shortcuts to see how you can make the most of your email time. And get to know Mail better with other tips and tricks you might not know about.