Soulbrand in Diablo 4 is a unique chest armor with multiple protective elements, ideal for increasing your survivability in endgame zones. It provides maximum health boosts, damage reduction while healthy, barrier generation, and increased potion capacity. This barrier can be very useful for characters who rely on defense or have difficulty surviving enemy attacks.

Additionally, with this item, your healing potion will no longer heal instantly, but instead will grant a Barrier for 200% of the original healing for 4 seconds. You gain Damage Reduction while you have a Barrier, and you can drink your Healing Potion while at full Life. If you like what it offers for your build, you can find Soulbrand in D4 here.

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Soulbrand can be dropped by two bosses – Duriel, King of Maggots and Andariel. So, target farm these two enemies (you'll need a lot of summon materials) and you can get Soulbrand from either run.