It's a tough world for “Nightbitch” at TIFF.

Marielle Heller’s long-awaited dramedy made its world premiere Saturday at the Toronto International Film Festival, exactly five years after her previous film, “A Beautiful Day in the Neighborhood,” debuted at the Canadian festival. Heller was joined by producers, author Rachel Yoder (on whose book the film is based) and stars Amy Adams and Scoot McNairy. Twin child actors Arleigh Patrick Snowden and Emmett James, who share the role of the “son,” charmed the audience with stuffed dogs and a message: “We hope you enjoy the film.”

“Nightbitch” follows an unnamed mother played by Adams who takes a break from her career as an artist to become a stay-at-home mom. Two years into her motherhood, her domesticity begins to take a surreal turn.

“One of the beautiful explorations of the film is this isolation that comes from [having children], and the transformation of motherhood and parenthood is something that is a shared experience, and yet it’s not shared,” Adams noted during the Q&A portion after the film. “So, it’s such a gift to be a part of sharing that with all of you, and sharing it through the process of making the film.”