When law professor Annalise Keating (Viola Davis) named her Middleton University course How to Get Away With Murder, she didn’t expect her own students to take violent turns. Yet some did when they became entangled in Annalise’s tumultuous personal life. And by the end of ABC’s six-season How to Get Away With Murder, there were no good men left … except, perhaps, kind-hearted hacker Oliver Hampton (Conrad Ricamora).

The blood began to flow when HTGAWM's series premiered 10 years ago, on September 25, 2014. To celebrate the legal thriller's 10th anniversary, we identify our picks for the show's 10 greatest villains…

Played by Billy Brown, this Philadelphia detective broke the law on multiple occasions—and also broke his marriage vows, sleeping with Annalise even as his wife was dying of cancer. He later nearly beat prosecutor Ronald Miller (John Hensley) to death after believing that Ronald was responsible for his father's death. And when he realized that the man responsible was actually Xavier Castillo (Gerardo Celasco), he snapped that man's neck.

Annalise's star students learned firsthand how to get away with murder — at least for a while — by covering up the murder of Annalise's husband (more on him later) at the hands of Wes Gibbins (Alfred Enoch) and Michaela Pratt (Aja Naomi King). The gang also kidnapped fellow student Rebecca Sutter (Katie Findlay) after she threatened to expose them. Later, Asher Millstone (Matt McGorry) murdered ADA Emily Sinclair (Sarah Burns) for smearing his father before the group framed someone else for her death, Michaela turned Simon Drake (Behzad Dabu) over to ICE after he got in their way, and Laurel Castillo (Karla Souza) arranged to have her father (more on him later) killed in prison.